New radiopharmaceuticals under development in Kazakhstan

In recent years, nuclear medicine has proven itself as one of the most effective methods for treating cancer in Kazakhstan. For its early diagnosis and treatment, the Institute of Nuclear Physics produces 90 percent of radiopharmaceuticals. Moreover, they produce three main drugs, two of them based on the radioisotopes iodine-131 and technetium-99m are made at the nuclear research reactor.

«Almost all organs and systems can be examined using technetium and a kit chosen by the doctor. The gold standard in nuclear medicine is the control of bone metastases. The kit is labeled with technetium, administered to the patient, and if there are bone metastases in cancer, they are clearly visible during the examination,» said Yelena Chakrova, head of the Radiochemistry and Izotope Production Center at the Institute of Nuclear Physics.

New drugs based on the fluorine-18 isotopes and lutetium-177 are currently being developed. Doctors say that they are essential for diagnosing prostate cancer, and successful treatment depends on early detection, which is carried out with the help of another Kazakh drug - fluorodeoxyglucose 18F.

«Radiopharmaceuticals in medicine use short-lived or ultra-short-lived isotopes. We cannot import them from other countries as the transportation time must not exceed four hours for fluorodeoxyglucose, for example. Therefore, we cannot bring this radiopharmaceutical from other countries and distant regions, we must produce it here,» noted Jandos Amankulov, head of the Department of Radiology and Nuclear Medicine at the Kazakh Institute of Oncology and Radiology.

This year, the first delivery of these vital medications was made to the Kyrgyz Republic. Notably, diagnosis and treatment of cancer diseases are currently conducted in nine nuclear medicine centers in Kazakhstan. Plans are in place to open several more centers in Astana, Aktobe, Karagandy, and Oskemen. The country intends to further develop nuclear medicine, with a key role to be played by nuclear power. Domestic scientists, guided by the experience of South Korea, Japan, and the U.S., will introduce advanced technologies.